Ethyl malonate
Chemically colorless liquid with a sweet ether odor.
It is mixed with alcohol, ether, soluble in chloroform, benzene and other organic solvents.
Slightly soluble in water.
At 20 ℃ water solubility is 2.08 g / 100 ml.
Use of GB 2760 a 96 to allow the use of edible spices.
It is mainly used for fruit essence, such as pear, apple, grape, cherry etc.
Use diethyl malonate is the preparation of 2 - amino - 4, 6 - dimethoxy pyrimidine important intermediates, can be used for the preparation of sulfonylurea herbicides, such as benzyl its cycling, pyrazole its cycling, smoke its cycling, etc., and medicine intermediates for sulphonamide and barbital.
Diethyl malate is an organic synthesis intermediate.
In dyes, spices, sulfonylurea herbicides, such as widely used in production, diethyl malonate is mainly used in the production of ethoxy methylene, barbituric acid, alkyl malonic diethyl ester, and synthetic medicine such as beauty effect of norfloxacin, chloroquine, bute and synthetic dyes and pigments such as benzene and imidazole ketone organic pigments.
Diethyl foreign malonate is mainly used to produce ethoxy, barbiturate and diethyl alkylate.
USES 1. Pharmaceutical intermediates.
It can be used for the synthesis of pharmaceutical such as sulfonamide, barbiturate, chloroquine, and teratin.
Use for ammonia and potassium.
Gas chromatographic stationary liquid (highest use temperature 40 ℃, the solvent of benzene, chloroform, ethanol).
Solvent for resin and nitrocellulose, plasticizer.
In organic synthesis.
It is used as the intermediate body of pharmaceutical, sulfonamide and barbiturate, which is also the middle body of spices and dyes
Production methods diethyl malonate production methods mainly by cyanide esterification method and catalytic carbonylation method, the industry is still widely accepted traditional cyanide esterification method.
It is obtained by neutralizing, cyaniding, hydrolyzing and esterification.
Chloroacetic acid with sodium carbonate and sodium chloroacetate is generated in 30 ℃, in 92-92 ℃ with sodium cyanide, cyanide is generated by alkaline hydrolysis and malonic acid sodium.
Malonic acid sodium after drying in the presence of sulfuric acid esterification with ethanol in 70-72 ℃.
The product of the esterified product was washed and distilled.
Raw material consumption quota: chloroacetic acid (95%) 650kg/t, sodium cyanide (95%) 340kg/t, ethanol (95%) 910kg/t.
Abroad to develop new technology mainly catalytic carbonylation method, namely the chloroacetic acid ester, carbon monoxide, ethanol as raw material, the catalyst is the next step reaction synthesis of diethyl malonate.
In contrast, the catalytic carbonylation process, along with the sodium cyanide method, is directly esterified by cyanide and ethanol.
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It is mixed with alcohol, ether, soluble in chloroform, benzene and other organic solvents.
Slightly soluble in water.
At 20 ℃ water solubility is 2.08 g / 100 ml.
Use of GB 2760 a 96 to allow the use of edible spices.
It is mainly used for fruit essence, such as pear, apple, grape, cherry etc.
Use diethyl malonate is the preparation of 2 - amino - 4, 6 - dimethoxy pyrimidine important intermediates, can be used for the preparation of sulfonylurea herbicides, such as benzyl its cycling, pyrazole its cycling, smoke its cycling, etc., and medicine intermediates for sulphonamide and barbital.
Diethyl malate is an organic synthesis intermediate.
In dyes, spices, sulfonylurea herbicides, such as widely used in production, diethyl malonate is mainly used in the production of ethoxy methylene, barbituric acid, alkyl malonic diethyl ester, and synthetic medicine such as beauty effect of norfloxacin, chloroquine, bute and synthetic dyes and pigments such as benzene and imidazole ketone organic pigments.
Diethyl foreign malonate is mainly used to produce ethoxy, barbiturate and diethyl alkylate.
USES 1. Pharmaceutical intermediates.
It can be used for the synthesis of pharmaceutical such as sulfonamide, barbiturate, chloroquine, and teratin.
Use for ammonia and potassium.
Gas chromatographic stationary liquid (highest use temperature 40 ℃, the solvent of benzene, chloroform, ethanol).
Solvent for resin and nitrocellulose, plasticizer.
In organic synthesis.
It is used as the intermediate body of pharmaceutical, sulfonamide and barbiturate, which is also the middle body of spices and dyes
Production methods diethyl malonate production methods mainly by cyanide esterification method and catalytic carbonylation method, the industry is still widely accepted traditional cyanide esterification method.
It is obtained by neutralizing, cyaniding, hydrolyzing and esterification.
Chloroacetic acid with sodium carbonate and sodium chloroacetate is generated in 30 ℃, in 92-92 ℃ with sodium cyanide, cyanide is generated by alkaline hydrolysis and malonic acid sodium.
Malonic acid sodium after drying in the presence of sulfuric acid esterification with ethanol in 70-72 ℃.
The product of the esterified product was washed and distilled.
Raw material consumption quota: chloroacetic acid (95%) 650kg/t, sodium cyanide (95%) 340kg/t, ethanol (95%) 910kg/t.
Abroad to develop new technology mainly catalytic carbonylation method, namely the chloroacetic acid ester, carbon monoxide, ethanol as raw material, the catalyst is the next step reaction synthesis of diethyl malonate.
In contrast, the catalytic carbonylation process, along with the sodium cyanide method, is directly esterified by cyanide and ethanol.